Active B6
Pyridoxal-5-Phosphate (P5P) is the metabolically active form of vitamin B6 found in the body, and is known to be necessary for the transformation and utilisation of amino acids for many functions in the body, including energy production and neurotransmitter synthesis.
Activated B6 plays a crucial role in supporting the Methylation and Transulfation pathways and is involved in the production of hemoglobin, Intrinsic Factor, and is a vital component in the formation of the Myelin sheath that surrounds nerve cells
Metabolically Active Form
For vitamin B6 to be utilised by the body, it must first be converted to P5P in the liver. Individuals with compromised liver function may not be able to efficiently make this conversion, and consequently may be at risk of a vitamin B6 deficiency. Out of 31 patients with impaired liver function, 22 had significantly lower plasma P5P levels than normal. Supplementing with RN Labs Active B6 ensures patients receive the most bioactive form of vitamin B6.
Schaumburg, H, Kaplan, J, Windebank, A, Vick, N, Rasmus, S, Pleasure, D & Brown, MJ 1983, ‘Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome’, The New England Journal of Medicine, vol. 309, pp. 445-8.
Labadarios, D, Rossouw, JE, McConnell, JB, Davis, M & Williams, R 1977, ‘Vitamin B6 deficiency in chronic liver disease – evidence for increased degradation of pyridoxal-5-phosphate’, Gut, vol. 18, pp. 23-7.
- The most ‘activated’ supplemental form of vitamin B6
- Involved in the metabolism of nearly all amino acids, as a coenzyme for reactions such as transamination and decarboxylation and the production of non-essential amino acids
- An important coenzyme for neurotransmitter biosynthesis
- May assist in the maintenance of normal healthy nerve and brain function
- May assist in the management of pre-menstrual tension/syndrome
- May help reduce the severity of nausea and vomiting during pregnancy
- Required in heme biosynthesis (Porphyrin pathway) and the formation of hemoglobin
- Required for conversion of homocysteine to Cysteine in the transulfation pathway
- Required for the conversion of folates in the methylation cycle
Suggested Use: Adults take 1-2 capsules daily or as prescribed by your healthcare practitioner.
As a source of Vitamin B6, is pyridoxal-5-phosphate associated with peripheral neuropathy like Pyridoxine HCL?
The active form of B6, Pyridoxal-5-phosphate has not been associated with peripheral neuropathy, as Pyridoxine salts have been.
The label warning is a TGA requirement applied to all forms of Vitamin B6 regardless of chemical composition.
This product contains Pyridoxal-5-Phosphate which may be dangerous when used in large amounts or for a long time.
If symptoms persist consult your healthcare practitioner.
Vitamin and/or mineral supplements should not replace a balanced diet.
If pregnant, consult your healthcare practitioner before using this product.
Known Side Effects
The use of supplemental P5P has not been associated with toxicity, although the inactive form, pyridoxine, has been associated with peripheral neuropathy.
RN Labs Active B6 is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.
Example Case Study: PMS Symptoms
Sylvia, a 26 year old female came into the initial consult with complaints of experiencing a strong case of Premenstrual Syndrome (PMS) to the point that it was affecting her life…
